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Clinical Evidence for PVI

Clinical Evidence for PVI Graph

PVI has been shown to predict fluid responsiveness, defined as a significant increase in cardiac output after fluid administration.

  • > PVI > 14% prior to volume expansion is highly predictive that a patient will respond to fluid administration (81% sensitivity)
  • > PVI < 14% prior to volume expansion is highly predictive that a patient will not respond to fluid administration (100% specificity)

Adapted from Cannesson M. et. al. Br J Anesth 2008;101(2):200-206

PVI showed a similar accuracy (0.93 area under the curve, AUC) vs. pulse pressure variation from an invasive arterial catheter (0.94) and superior accuracy vs. cardiac index (0.56), central venous pressure (0.42), and pulmonary capillary wedge pressure (0.40).